Protective effect of myricetin on osmotic stability of erythrocytes during aging in humans

Enhanced oxidative stress is reported as one of the main determinants of aging and age related events. Several parameters of blood have been demonstrated to be negatively affected by increased oxidative stress including changes in erythrocyte membrane fluidity and integrity, which results into overall malfunctioned cellular physiology. Present study was aimed to determine the erythrocyte osmotic stability during aging in humans and the effect of myricetin treatment. Results obtained from the study show a significant (p < 0.0001) age dependent decline in the stability of erythrocyte as evidenced by enhanced osmotic fragility in aged individuals which was significantly correlated with radical scavenging capacity of plasma. Myricetin at 10μM significantly (p < 0.05) protected osmotic lysis of erythrocytes obtained from different age subjects.